What is the relationship between intelligence and the material world? In confirmation of John 1:1, “In the beginning was the Word,” there is a top-down flow of control such that the thermodynamics of DNA is essentially governed by software in a similar way to how man-made digital computers are controlled by programmed algorithms originating from intelligent minds. This session will examine how the language of DNA connects with thermodynamics and show how a Christian worldview provides a framework for new research. It is shown that the remarkable efficiency of information transfer in DNA is close to the minimum possible.