This session will explore some of the new scientific advances at either end of life and the ethical and spiritual issues associated with them. New advances at the initiation of human life include stem cell-based embryo models (SCBEMs), ‘same sex reproduction’ and ectogestation. End of life dilemmas include increasing uncertainties about brain death diagnosis, disputes around the dead donor rule, the use of extracorporeal membrane oxygenation (ECMO), and reversal of ageing in cells.