A Christian worldview provides a more comprehensive framework for understanding and treating depression than does the secular, materialistic framework that currently dominates psychiatry and psychotherapy. In addition to taking into account the biological and psychosocial dimensions of depression from a Christian worldview standpoint, attention to personalist, ethical, and spiritual features is also necessary to address depression holistically – as a human disorder. A case study of a person with depression will be presented to illustrate the value of a Christian approach to diagnosis and treatment.