Most underlying values and core principles of scholarly research are good and praiseworthy. However, just like everything else, when detached from a relationship with God, many of them can become misguided and dysfunctional. In this joint interactive session with the Academic and Scientists Networks, we will take a critical yet hopeful look at spiritual challenges and opportunities that arise in our individual and collective pursuits of scientific knowledge. We will share experiences and insights on how Christians working in academia can cultivate an ethos rooted in trust and dependence on the Lord, rather than relying solely on their own abilities.